High-Density Lipoprotein Levels Have Markedly Increased Over the Past Twenty Years in Japan
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منابع مشابه
Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels.
It has been proposed that the plasma phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids and cholesterol from triglyceride-rich lipoproteins (TRL) into high-density lipoproteins (HDL). To evaluate the in vivo role of PLTP in lipoprotein metabolism, we used homologous recombination in embryonic stem cells and produced mice with no PLTP gene expression. Analysis of plas...
متن کاملApolipoprotein E Improves High-Density Lipoprotein Function, and Markedly Reduces Atherosclerosis in Oral Synthetic Phospholipid (DMPC) Raises High-Density Lipoprotein Cholesterol Levels,
Null Mice − Apolipoprotein E Improves High-Density Lipoprotein Function, and Markedly Reduces Atherosclerosis in Oral Synthetic Phospholipid (DMPC) Raises High-Density Lipoprotein Cholesterol Levels, Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2003 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, ...
متن کاملOral synthetic phospholipid (DMPC) raises high-density lipoprotein cholesterol levels, improves high-density lipoprotein function, and markedly reduces atherosclerosis in apolipoprotein E-null mice.
BACKGROUND Lecithin has been widely sold as a dietary supplement. 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a phospholipid that does not exist in nature and has been used in vitro to study lipid binding. We tested DMPC in vivo in apolipoprotein (apo) E-null mice. METHODS AND RESULTS DMPC or soy or egg lecithin at 1.0 mg/mL was added to the drinking water of 4-week-old apoE-null fe...
متن کاملBeyond High-Density Lipoprotein Cholesterol Levels
A number of therapeutic strategies targeting high-density lipoprotein (HDL) cholesterol and reverse cholesterol transport are being developed to halt the progression of atherosclerosis or even induce regression. However, circulating HDL cholesterol levels alone represent an inadequate measure of therapeutic efficacy. Evaluation of the potential effects of HDL-targeted interventions on atheroscl...
متن کاملIdentification of Sequence Variation in the Apolipoprotein A2 Gene and Their Relationship with Serum High-Density Lipoprotein Cholesterol Levels
Background: Apolipoprotein A2 (APOA2) is the second major apolipoprotein of the high-density lipoprotein cholesterol (HDL-C). The study aim was to identify APOA2 gene variation in individuals within two extreme tails of HDL-C levels and its relationship with HDL-C level. Methods: This cross-sectional survey was conducted on participants from Tehran Glucose and Lipid Study (TLGS) at Research Ins...
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ژورنال
عنوان ژورنال: Journal of Atherosclerosis and Thrombosis
سال: 2014
ISSN: 1340-3478,1880-3873
DOI: 10.5551/jat.20909